Rarely did a protocol or policy get in the way of need when that need meant damage to the bottom line unless that need were met. If a major right of way for main line running had to run 10' away from an engine house or an interchange or a turntable, even to the extent of having large coaling towers straddling the mains, it was done. The only absolutes were the restrictions of gauge loading to ensure safe clearances.
With that said, our layouts are highly compressed representations of real railroads or notionalized ones, fanciful ones. We should do what is plausible and effective in order to keep our curves wide, or tight, to maintain clearances and ease of operations, and to be able to close loops of main track if that type of running is an important component of what each of us terms 'fun'.