I agree with Chip. You obviously want a grand layout, the grandest you can get in your space, something with a really long mainline run. Unfortunately, if you pursue this course, your track plan will be an over and under spaghetti bowl, even if symmetrical as you have drawn it. If you do a sinuous path around the general perimeter, including the lone bridge to get past the door, as Chip suggests, you will have a nice long mainline run. That will occupy you, and thrill you, about 40-60% of the time. But what will happen for pleasure the rest of the time? You must have some switching, some storage capacity in the way of a yard, even if it is as little as three parallel tracks each about 4' long.
There is room in your space for hills, bridges, tunnels, culverts and such, and room for a small town. The town should have at least one major employer, who, funnily enough, happens to be served by the railroad. Somewhere out in the boonies, on the opposite side of the room, there is a small molybdenum and copper mine, or a coal mine, or a brewery, or a farm or sawmill...something that will require a few cars set out and some filled ones to be taken back to the yard for distribution forwarding to points elsewhere...the market. Once you have had your 10 solid minutes of enjoying your trains whizzing along the main, you will find yourself wanting to break up a train, make a new one, and then do some industrial servicing. What you have depicted makes no provision for it. Instead, you have a very complicated series of whorls and overpasses that are meant to get the widest curves possible and the longest run with which you will hopefully never have to interfere. After it is built, it will still amount to an under-the-Christmas-tree roundy train set that goes nowhere.
There is nothing wrong with having a firm resolve to include an important, even critical, component in your layout, and mostly so in your first. If nothing else, it will teach you a lesson...it was a great decision or a poor one. Most people accept, at the last, that cramming a long single-purpose main into a defined space was not the best decision...not then, not later.
Really, the best track plans are analogs of the wiring that serves them. If you think of the heavier gauge wire that runs below the main line, with feeders up to provide a service here and there....that is precisely how a railroad looks from the satellite's view. It doesn't fold back and cross over itself five or six times only to form a closed loop so that the "owner" never has to turn his locomotive to run the other way...once in a while. Engines are designed to, and do, run in reverse for extended distances when they must.
If you'd like a loop, use the bridge at the door and run around the perimeter, or build a dog bone with the two lumps. Dog bones can be folded so that you have the neat grade and single overpass if that is desired, almost always at the midpoint between the two bulges at the end. It has been the resort of thousands.
-Crandell