Grades may be grades, but model trains aren't the same as actual trains, particularly when it comes to tractive effort, wheel slip/friction, etc. Woodland Scenics sells 4% styrafoam grade materials, for model railroads. A number of years ago, modelers weren't always concerned about strickley limiting their grades to 2%, which on an actual Class 1 mainline railroad, would be considered a fairly difficult for a train of typical length, with a normal loco consist, regardless of whether helpers/distributed power were used or not.
For most model railroads, a typical length freight train isn't 60 loads, with the appropriate amount of weight added to represent the load, nor the distances like in a real world. Grades of 3-5% were some times the norm, as it meant that helpers on the model railroad would really be required to move the train of 15 cars up to the next locale. And if it meant that you could add a model feature that you desired (viaduct, trestle, bridge, etc), which would add scenic interest to your layout, a 3-5% grade might just be the result. Its your railroad after all-model railroading is/was supposed to be done for fun. I assume, if Woodland Scenics didn't think there was a demand for 4% grade sytrafoam material, they wouldn't make it, as there wouldn't be any money in it for them.
TGV lines in Europe when they were first built, were straight, regardless of the terrain. Meant some very long tunnels, or steeper grades than desired, as what mattered was travel time between end points, not other stuff.
Good luck!