Cut it down to 2' wide or less and do a small switching layout.
That is one option, but it really comes back to what Chuck wants from his layout.
If he wants continuous run, a point to point layout (unless it is a trolley layout or an automatic reversing pendulum push-pull passenger service) is probably not the best choice.
If he wants modern era trains with long cars or big steam engines, the 20-22" radius imposed by doing a closed loop layout in H0 scale on a four foot deep table is probably not a great idea.
But going to N scale would turn that space into a huge layout - 4 x 10 feet in N scale is the equivalent of 7 x 18 feet in H0 scale.
On the other hand, if he in H0 scale wants to run small 4-axle diesel locomotives and modest length trains - say 7-8-9 40' cars, 18-22" radius is not a big problem.
If he wants to sit or stand in one spot and watch trains run past, it may make sense to use half the table (behind a backdrop) for "staging" (i.e. holding trains waiting to go on stage, and model a small town of some kind on the front half of the layout, where he makes one train take the siding to let another train past, or have one train set out a cut of cars, while a local freight train later places cars at industries, and take away outbound cars from the industries.
If he wants to walk along with his train, he could do two scenes - which would be very different depending on whether he wants to model a logging line in New Hampshire in the 1920s, narrow gauge railroading in Colorado, a granger in Iowa, coal railroading in the Appalachians, urban switching in Brooklyn, switching modern warehouses in Miami and so on and so forth.
If what he wants is more of an amusement park ride look - i.e. trains that pop into and out of tunnels in unexpected places, loop around, crisscrossing it's track above and below the path it followed moments ago, that is also possible - but it takes a totally different type of track plan.
So it would probably be smart if Chuck added some more information on what he likes, and how the layout will be fitted into the room.
Smile,
Stein