There is one drawback to N scale that hasn't been mentioned yet:
Over 90% of current passenger and freight cars have truck-mounted couplers. While I've gotten used to that, there are times when I really notice it, such as when trying to back a long train around a curve, or through a turnout.
Of course, I consider it a cost of being able to have a really nice, well-detailed layout that's 30 inches x10 feet. A comparable layout in HO would be almost 6 feet wide, and over 20 feet long, plus I would have to have it away from the wall for access on the back side, something I don't have to do with N (it stays up against the wall).
When it absolutely, positively, has to get there (someday), ship on the ES&BM.