Are the drivers sprung? If so, they may catch on the inside top of the rails when the locomotive comes out of the curve. If not, you may be okay. Another possibility would be to remove the flanges from the drivers in front and in back of the blind one. That would, of course, entail disassembly and turning of the drivers on a lathe or drill press. You'd need to remove one driver from each axle in order to chuck the axle up in the press or lathe. You'd then have to re-install the turned driver, remove the opposite one, turn off the flange, reinstall the other driver and then re-quarter them all to match. A LOT of work, but might be necessary. Personally, I've kitbashed Mantua Mikados into 2-10-2's and 2-10-4's with all but the end drivers blind and shimmed .010" so the blind driver don't touch the tops of the rails. You can't see the gap unless you get right down next to them with a light behind the locomotive, but I can run them around 18-inch radius curves without any problem!